# TRAK1

Source: https://onco.cc/targets/trak1/  
OnCo record `trak1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TRAK1 (Trafficking kinesin-binding protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors. Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility.

Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.39, affected pathway 0.89, animal model 0.36, genetic association 0.32).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: trafficking kinesin protein 1; Trafficking kinesin-binding protein 1; OIP106; KIAA1042; MILT1
- Tags: cancer-genes-wave
- Symbol: TRAK1
- Class: other
- Biology: Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors. Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes. TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain-independent, anterograde transport of mitochondria. Location: Cytoplasm; Nucleus; Mitochondrion; Early endosome (UniProt). Locus 3p22.1 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:29947: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29947
- UniProt Q9UPV9: https://www.uniprot.org/uniprotkb/Q9UPV9/entry
- NCBI Gene 22906: https://www.ncbi.nlm.nih.gov/gene/22906
- Ensembl ENSG00000182606: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000182606

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/trak1.json