# TRIM28

Source: https://onco.cc/targets/trim28/  
OnCo record `trim28` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TRIM28 (Transcription intermediary factor 1-beta) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Wilms tumour.

## Summary

E3 SUMO and ubiquitin ligase that plays a pivotal role in embryonic development, genomic imprinting, and maintenance of genomic stability through repression of repetitive and retroviral elements. Also involved in DNA repair, regulation of innate immunity or cellular energy homeostasis. Acts as a scaffold for assembling transcriptional repression complexes containing methyltransferases, histone deacetylases, and chromatin remodelers.

Open Targets scores its association with cancer at 0.70 (direct and indirect evidence; datatypes literature 0.99, genetic association 0.81, somatic mutation 0.23, genetic literature 0.76).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: tripartite motif containing 28; Transcription intermediary factor 1-beta; TIF1B; KAP1; TF1B; RNF96; PPP1R157; KAP-1; TIF1-beta; TIF1beta
- Tags: cancer-genes-wave
- Symbol: TRIM28
- Class: transcription
- Biology: E3 SUMO and ubiquitin ligase that plays a pivotal role in embryonic development, genomic imprinting, and maintenance of genomic stability through repression of repetitive and retroviral elements. Also involved in DNA repair, regulation of innate immunity or cellular energy homeostasis. Acts as a scaffold for assembling transcriptional repression complexes containing methyltransferases, histone deacetylases, and chromatin remodelers. Serves as a nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs), mediating gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1, which methylates histone H3 at 'Lys-9' (H3K9me), leading to heterochromatin formation. In collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway. Functions as a coactivator for CEBPB and NR3C1 (glucocorticoid receptor) in transcriptional activation of ORM1, and as a corepressor for ERBB4. Location: Nucleus (UniProt). Locus 19q13.43 (HGNC).
- Where found: Wilms tumour: Open Targets association 0.67 with Wilms tumour (MONDO_0006058)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:16384: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16384
- UniProt Q13263: https://www.uniprot.org/uniprotkb/Q13263/entry
- NCBI Gene 10155: https://www.ncbi.nlm.nih.gov/gene/10155
- Ensembl ENSG00000130726: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000130726

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Wilms tumour (nephroblastoma)](https://onco.cc/cancers/wilms-tumor/)

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JSON: https://onco.cc/api/v1/entities/trim28.json