# TRIM33

Source: https://onco.cc/targets/trim33/  
OnCo record `trim33` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TRIM33 (E3 ubiquitin-protein ligase TRIM33) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Lung cancer, Breast cancer, Colorectal cancer and 1 more.

## Summary

Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4.

Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.97, animal model 0.41, genetic association 0.02, somatic mutation 0.98). IntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Medulloblastoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: tripartite motif containing 33; E3 ubiquitin-protein ligase TRIM33; TIF1GAMMA; FLJ11429; KIAA1113; TIFGAMMA; RFG7; TF1G; TIF1G; PTC7
- Tags: cancer-genes-wave
- Symbol: TRIM33
- Class: tumor-suppressor
- Biology: Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signalling cascade. Plays a role in the control of cell proliferation. Location: Nucleus (UniProt). Locus 1p13.2 (HGNC).
- Where found: Lung cancer: Open Targets association 0.53 with lung cancer (MONDO_0008903); Breast cancer: Open Targets association 0.53 with breast cancer (MONDO_0007254); Colorectal cancer: Open Targets association 0.50 with colorectal cancer (MONDO_0005575); Medulloblastoma: IntOGen driver in 2 cohorts (MBL)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:16290: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16290
- UniProt Q9UPN9: https://www.uniprot.org/uniprotkb/Q9UPN9/entry
- NCBI Gene 51592: https://www.ncbi.nlm.nih.gov/gene/51592
- Ensembl ENSG00000197323: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000197323

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Medulloblastoma](https://onco.cc/cancers/medulloblastoma/)

---
JSON: https://onco.cc/api/v1/entities/trim33.json