# TRIM49C

Source: https://onco.cc/targets/trim49c/  
OnCo record `trim49c` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TRIM49C (Tripartite motif-containing protein 49C) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Gastric & gastro-oesophageal junction cancer.

## Summary

UniProt has no function text for P0CI26; HGNC names it "tripartite motif containing 49C".

IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Stomach Adenocarcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: tripartite motif containing 49C; Tripartite motif-containing protein 49C; TRIM49L2
- Tags: cancer-genes-wave
- Symbol: TRIM49C
- Class: oncogene
- Biology: UniProt has no function text for P0CI26; HGNC names it "tripartite motif containing 49C". Locus 11q14.3 (HGNC).
- Where found: Gastric & gastro-oesophageal junction cancer: IntOGen driver in 1 cohort (STAD)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:38877: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:38877
- UniProt P0CI26: https://www.uniprot.org/uniprotkb/P0CI26/entry
- NCBI Gene 642612: https://www.ncbi.nlm.nih.gov/gene/642612
- Ensembl ENSG00000204449: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000204449

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/)

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JSON: https://onco.cc/api/v1/entities/trim49c.json