# TROP2 CAR/IL-15 cord-blood NK cells

Source: https://onco.cc/drugs/trop2-car-il15-cord-blood-nk/  
OnCo record `trop2-car-il15-cord-blood-nk` (Treatment). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

These experimental immune cells are designed to recognize TROP2 on cancer cells. Early trials are studying their safety and activity.

## Summary

AACR 2026 abstract CT294 describes the TROPIKANA phase 1 protocol in advanced TROP2-positive solid tumors, with lymphodepletion and engineered cord-blood NK cells. It reports trial design and first treatment in January 2024, not a clinical response or survival result. NCT06066424 is recruiting with 54 planned participants. A separate colorectal minimal-residual-disease study, NCT06358430, combines this cell platform with cetuximab; it does not establish postoperative TNBC benefit.

## Fields

- Kind: Treatment
- Status: phase-1
- Last checked: 2026-10-06
- Modality: CAR-NK cell therapy
- Mechanism: Cord-blood natural killer cells engineered with a TROP2 CAR, IL-15 to support persistence, and an inducible caspase-9 safety switch.

## Sources

- Publisher abstract: https://doi.org/10.1158/1538-7445.am2026-ct294
- Publisher abstract: https://doi.org/10.1200/jco.2026.44.2_suppl.tps275
- ClinicalTrials.gov NCT06066424: https://clinicaltrials.gov/study/NCT06066424
- ClinicalTrials.gov NCT06358430: https://clinicaltrials.gov/study/NCT06358430

## Connected records

- technologies: [CAR-NK & CAR-macrophage](https://onco.cc/technologies/car-nk-macrophage/)
- targets: [TROP2](https://onco.cc/targets/trop2/)
- trials: [Dose Escalation and Expansion Study of TROP2 CAR Engineered IL-15- Transduced Cord Blood-derived NK Cells in Combination With Cetuximab in Patient With Colorectal Cancer (CRC) With Minimal Residual Disease (MRD)](https://onco.cc/trials/nct06358430/), [Phase 1 Dose Escalation and Expansion Study of TROP2 CAR Engineered IL15-transduced Cord Blood-derived NK Cells in Patients With Advanced Solid Tumors (TROPIKANA)](https://onco.cc/trials/nct06066424/)

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