# TSPYL1

Source: https://onco.cc/targets/tspyl1/  
OnCo record `tspyl1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TSPYL1 (Testis-specific Y-encoded-like protein 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.

## Summary

UniProt has no function text for Q9H0U9; HGNC names it "TSPY like 1".

CIViC holds 2 clinical evidence items and 0 assertions across 2 variants, naming Abiraterone and Prednisone.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: TSPY like 1; Testis-specific Y-encoded-like protein 1; TSPYL
- Tags: cancer-genes-wave
- Symbol: TSPYL1
- Class: other
- Biology: UniProt has no function text for Q9H0U9; HGNC names it "TSPY like 1". Location: Nucleus, nucleolus (UniProt). Locus 6q22.1 (HGNC).
- Where found: Prostate cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:12382: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12382
- UniProt Q9H0U9: https://www.uniprot.org/uniprotkb/Q9H0U9/entry
- NCBI Gene 7259: https://www.ncbi.nlm.nih.gov/gene/7259
- Ensembl ENSG00000189241: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000189241

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Prostate cancer](https://onco.cc/cancers/prostate/)

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JSON: https://onco.cc/api/v1/entities/tspyl1.json