# TTF1

Source: https://onco.cc/targets/ttf1/  
OnCo record `ttf1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TTF1 (Transcription termination factor 1) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.

## Summary

Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: transcription termination factor 1; Transcription termination factor 1
- Tags: cancer-genes-wave
- Symbol: TTF1
- Class: transcription
- Biology: Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity. Location: Nucleus; Nucleus, nucleolus; Nucleus, nucleoplasm (UniProt). Locus 9q34.13 (HGNC).
- Where found: Non-small-cell lung cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:12397: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12397
- UniProt Q15361: https://www.uniprot.org/uniprotkb/Q15361/entry
- NCBI Gene 7270: https://www.ncbi.nlm.nih.gov/gene/7270
- Ensembl ENSG00000125482: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000125482

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)

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JSON: https://onco.cc/api/v1/entities/ttf1.json