# TUBB3

Source: https://onco.cc/targets/tubb3/  
OnCo record `tubb3` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TUBB3 (Tubulin beta-3 chain) is a gene. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Breast cancer, Lung cancer, Prostate cancer and 5 more.

## Summary

Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilising cap forms. Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

CIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Paclitaxel and Taxane Compound. Open Targets scores its association with cancer at 0.70 (direct and indirect evidence; datatypes clinical 1.00, affected pathway 0.61, literature 0.95, genetic association 0.28, somatic mutation 0.23, animal model 0.36).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: tubulin beta 3 class III; Tubulin beta-3 chain; beta-4; CFEOM3; CFEOM3A; FEOM3
- Tags: cancer-genes-wave
- Symbol: TUBB3
- Class: other
- Biology: Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilising cap forms. Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. TUBB3 plays a critical role in proper axon guidance and maintenance. Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerised TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Plays a role in dorsal root ganglion axon projection towards the spinal cord. Location: Cytoplasm, cytoskeleton; Cell projection, growth cone; Cell projection, lamellipodium; Cell projection, filopodium (UniProt). Locus 16q24.3 (HGNC).
- Where found: Breast cancer: Open Targets association 0.63 with breast cancer (MONDO_0007254); CIViC evidence names this disease; Lung cancer: Open Targets association 0.63 with lung cancer (MONDO_0008903); Prostate cancer: Open Targets association 0.63 with prostate cancer (MONDO_0008315); Non-Hodgkin lymphoma: Open Targets association 0.60 with non-Hodgkin lymphoma (MONDO_0018908); Hodgkin lymphoma: Open Targets association 0.59 with Hodgkins lymphoma (MONDO_0004952); Sarcomas: Open Targets association 0.59 with sarcoma (MONDO_0005089)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 1.00; CIViC holds 2 clinical evidence items on its variants. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:20772: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20772
- UniProt Q13509: https://www.uniprot.org/uniprotkb/Q13509/entry
- NCBI Gene 10381: https://www.ncbi.nlm.nih.gov/gene/10381
- Ensembl ENSG00000258947: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000258947

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Cervical cancer](https://onco.cc/cancers/cervical/), [Hodgkin lymphoma](https://onco.cc/cancers/hodgkin-lymphoma/), [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Multiple myeloma](https://onco.cc/cancers/multiple-myeloma/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/), [Prostate cancer](https://onco.cc/cancers/prostate/), [Sarcomas (soft tissue, bone, GIST)](https://onco.cc/cancers/sarcoma/)

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JSON: https://onco.cc/api/v1/entities/tubb3.json