# TUBB4A

Source: https://onco.cc/targets/tubb4a/  
OnCo record `tubb4a` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TUBB4A (Tubulin beta-4A chain) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Prostate cancer, Breast cancer, Lung cancer and 5 more.

## Summary

Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilising cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.87, animal model 0.53, genetic association 0.00, clinical 1.00).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: tubulin beta 4A class IVa; Tubulin beta-4A chain; beta-5; TUBB4; DYT4
- Tags: cancer-genes-wave
- Symbol: TUBB4A
- Class: other
- Biology: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilising cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Location: Cytoplasm, cytoskeleton (UniProt). Locus 19p13.3 (HGNC).
- Where found: Prostate cancer: Open Targets association 0.62 with prostate cancer (MONDO_0008315); Breast cancer: Open Targets association 0.61 with breast cancer (MONDO_0007254); Lung cancer: Open Targets association 0.61 with lung cancer (MONDO_0008903); Non-Hodgkin lymphoma: Open Targets association 0.60 with non-Hodgkin lymphoma (MONDO_0018908); Sarcomas: Open Targets association 0.59 with sarcoma (MONDO_0005089); Hodgkin lymphoma: Open Targets association 0.59 with Hodgkins lymphoma (MONDO_0004952)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 1.00. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:20774: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20774
- UniProt P04350: https://www.uniprot.org/uniprotkb/P04350/entry
- NCBI Gene 10382: https://www.ncbi.nlm.nih.gov/gene/10382
- Ensembl ENSG00000104833: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000104833

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Cervical cancer](https://onco.cc/cancers/cervical/), [Hodgkin lymphoma](https://onco.cc/cancers/hodgkin-lymphoma/), [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Multiple myeloma](https://onco.cc/cancers/multiple-myeloma/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/), [Prostate cancer](https://onco.cc/cancers/prostate/), [Sarcomas (soft tissue, bone, GIST)](https://onco.cc/cancers/sarcoma/)

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JSON: https://onco.cc/api/v1/entities/tubb4a.json