# Tubulin inhibitor payloads

Source: https://onco.cc/terms/tubulin-inhibitor-payloads/  
OnCo record `tubulin-inhibitor-payloads` (Term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Tubulin inhibitor payloads were the first generation of modern ADC payloads: drugs that jam the cell's scaffolding so it cannot divide. Nerve and eye side effects are typical.

## Summary

Auristatins (MMAE, MMAF) and maytansinoids (DM1, DM4) bind tubulin and arrest mitosis, so they work best in rapidly dividing tumours. Whether the released form crosses membranes decides the bystander effect: MMAE and DM4 do, MMAF and DM1 do not. Peripheral neuropathy (MMAE), keratopathy (MMAF, DM4) and thrombocytopenia (DM1) are the characteristic toxicities. Most are substrates for P-glycoprotein.

## Fields

- Kind: Term
- Last checked: 2026-09-09
- Also known as: auristatins; auristatin; maytansinoids; maytansinoid; microtubule payloads

## Sources

- Wikipedia: https://en.wikipedia.org/wiki/Mitotic_inhibitor
- Wikipedia: https://en.wikipedia.org/wiki/Mitotic_inhibitor

## Connected records

- terms: [Bystander effect (ADC)](https://onco.cc/terms/bystander-effect/), [DM1](https://onco.cc/terms/dm1/), [DM4](https://onco.cc/terms/dm4/), [Drug efflux pumps (ABC transporters)](https://onco.cc/terms/efflux-pump/), [MMAE](https://onco.cc/terms/mmae/), [MMAF](https://onco.cc/terms/mmaf/), [Ocular toxicity (keratopathy, blurred vision)](https://onco.cc/terms/ocular-toxicity/), [Payload (ADC)](https://onco.cc/terms/payload/), [Taxanes (paclitaxel, docetaxel, nab-paclitaxel)](https://onco.cc/terms/taxane/)
- technologies: [Antibody-drug conjugate (ADC)](https://onco.cc/technologies/adc/)
- drugs: [Belantamab mafodotin](https://onco.cc/drugs/belantamab-mafodotin/), [Brentuximab vedotin](https://onco.cc/drugs/brentuximab-vedotin/), [Disitamab vedotin](https://onco.cc/drugs/disitamab-vedotin/), [Enfortumab vedotin](https://onco.cc/drugs/enfortumab-vedotin/), [Mirvetuximab soravtansine](https://onco.cc/drugs/mirvetuximab-soravtansine/), [Sonesitatug vedotin](https://onco.cc/drugs/cmg901/), [Telisotuzumab vedotin](https://onco.cc/drugs/telisotuzumab-vedotin/), [Tisotumab vedotin](https://onco.cc/drugs/tisotumab-vedotin/), [Trastuzumab emtansine](https://onco.cc/drugs/trastuzumab-emtansine/), [Zilovertamab vedotin](https://onco.cc/drugs/zilovertamab-vedotin/)
- pathways: [Mitosis & the spindle assembly checkpoint](https://onco.cc/pathways/mitotic-spindle-checkpoint/)

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