# TYMP

Source: https://onco.cc/targets/tymp/  
OnCo record `tymp` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TYMP (Thymidine phosphorylase) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Colorectal cancer.

## Summary

May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. Catalyses the reversible phosphorolysis of thymidine.

Open Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes literature 0.96, genetic association 0.46, clinical 0.93).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: thymidine phosphorylase; Thymidine phosphorylase; MNGIE; ECGF1
- Tags: cancer-genes-wave
- Symbol: TYMP
- Class: enzyme
- Biology: May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. Catalyses the reversible phosphorolysis of thymidine. The produced molecules are then utilised as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Locus 22q13.33 (HGNC).
- Where found: Colorectal cancer: Open Targets association 0.58 with colorectal cancer (MONDO_0005575)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.93. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3148: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3148
- UniProt P19971: https://www.uniprot.org/uniprotkb/P19971/entry
- NCBI Gene 1890: https://www.ncbi.nlm.nih.gov/gene/1890
- Ensembl ENSG00000025708: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000025708

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/)

---
JSON: https://onco.cc/api/v1/entities/tymp.json