# TYW2

Source: https://onco.cc/targets/tyw2/  
OnCo record `tyw2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TYW2 (tRNA wybutosine-synthesising protein 2 homolog) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Salivary gland cancers.

## Summary

S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyses the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86.

IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Salivary Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: tRNA wybutosine-synthesizing protein 2; tRNA wybutosine-synthesizing protein 2 homolog; FLJ20772; Trm12; TRMT12
- Tags: cancer-genes-wave
- Symbol: TYW2
- Class: oncogene
- Biology: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyses the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86. Locus 8q24.13 (HGNC).
- Where found: Salivary gland cancers: IntOGen driver in 1 cohort (SACA)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:26091: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:26091
- UniProt Q53H54: https://www.uniprot.org/uniprotkb/Q53H54/entry
- NCBI Gene 55039: https://www.ncbi.nlm.nih.gov/gene/55039
- Ensembl ENSG00000183665: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000183665

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Salivary gland cancers](https://onco.cc/cancers/salivary-gland/)

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JSON: https://onco.cc/api/v1/entities/tyw2.json