# UBTF

Source: https://onco.cc/targets/ubtf/  
OnCo record `ubtf` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

UBTF (Nucleolar transcription factor 1) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Acute myeloid leukaemia.

## Summary

Recognises the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I (Pol I) through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element and can activate Pol I promoter escape.

CIViC holds 1 clinical evidence item and 2 assertions across 1 variant.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: upstream binding transcription factor; Nucleolar transcription factor 1; NOR-90; UBF1; UBF2
- Tags: cancer-genes-wave
- Symbol: UBTF
- Class: transcription
- Biology: Recognises the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I (Pol I) through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element and can activate Pol I promoter escape. Location: Nucleus, nucleolus (UniProt). Locus 17q21.31 (HGNC).
- Where found: Acute myeloid leukaemia: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:12511: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12511
- UniProt P17480: https://www.uniprot.org/uniprotkb/P17480/entry
- NCBI Gene 7343: https://www.ncbi.nlm.nih.gov/gene/7343
- Ensembl ENSG00000108312: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000108312

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Acute myeloid leukaemia](https://onco.cc/cancers/aml/)

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JSON: https://onco.cc/api/v1/entities/ubtf.json