# UBXN11

Source: https://onco.cc/targets/ubxn11/  
OnCo record `ubxn11` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

UBXN11 (UBX domain-containing protein 11) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Glioma & glioblastoma.

## Summary

May be involved in the reorganisation of actin cytoskeleton mediated by RND1, RND2 and RND3. Promotes RHOA activation mediated by GNA12 and GNA13.

IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Glioblastoma Multiforme.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: UBX domain protein 11; UBX domain-containing protein 11; UBXD5
- Tags: cancer-genes-wave
- Symbol: UBXN11
- Class: oncogene
- Biology: May be involved in the reorganisation of actin cytoskeleton mediated by RND1, RND2 and RND3. Promotes RHOA activation mediated by GNA12 and GNA13. Location: Cytoplasm, cytoskeleton (UniProt). Locus 1p36.11 (HGNC).
- Where found: Glioma & glioblastoma: IntOGen driver in 1 cohort (GBM)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:30600: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30600
- UniProt Q5T124: https://www.uniprot.org/uniprotkb/Q5T124/entry
- NCBI Gene 91544: https://www.ncbi.nlm.nih.gov/gene/91544
- Ensembl ENSG00000158062: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000158062

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Glioma & glioblastoma](https://onco.cc/cancers/glioblastoma/)

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JSON: https://onco.cc/api/v1/entities/ubxn11.json