# VAV1

Source: https://onco.cc/targets/vav1/  
OnCo record `vav1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

VAV1 (Proto-oncogene vav) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-small-cell lung cancer.

## Summary

Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.

IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Lung Adenocarcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: vav guanine nucleotide exchange factor 1; Proto-oncogene vav
- Tags: cancer-genes-wave
- Symbol: VAV1
- Class: tumor-suppressor
- Biology: Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. Locus 19p13.3 (HGNC).
- Where found: Non-small-cell lung cancer: IntOGen driver in 1 cohort (LUAD)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:12657: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12657
- UniProt P15498: https://www.uniprot.org/uniprotkb/P15498/entry
- NCBI Gene 7409: https://www.ncbi.nlm.nih.gov/gene/7409
- Ensembl ENSG00000141968: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000141968

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)

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JSON: https://onco.cc/api/v1/entities/vav1.json