# VCL

Source: https://onco.cc/targets/vcl/  
OnCo record `vcl` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

VCL (Vinculin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.

Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.96, affected pathway 0.97, genetic association 0.00).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: vinculin; Vinculin
- Tags: cancer-genes-wave
- Symbol: VCL
- Class: other
- Biology: Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. Location: Cell membrane; Cell junction, adherens junction; Cell junction, focal adhesion; Cytoplasm, cytoskeleton (UniProt). Locus 10q22.2 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:12665: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12665
- UniProt P18206: https://www.uniprot.org/uniprotkb/P18206/entry
- NCBI Gene 7414: https://www.ncbi.nlm.nih.gov/gene/7414
- Ensembl ENSG00000035403: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000035403

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/vcl.json