# VEGFC

Source: https://onco.cc/targets/vegfc/  
OnCo record `vegfc` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

VEGFC (Vascular endothelial growth factor C) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.

## Summary

Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Sunitinib.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: vascular endothelial growth factor C; Vascular endothelial growth factor C; VEGF-C
- Tags: cancer-genes-wave
- Symbol: VEGFC
- Class: other
- Biology: Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors. Location: Secreted (UniProt). Locus 4q34.3 (HGNC).
- Where found: Hepatocellular carcinoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:12682: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12682
- UniProt P49767: https://www.uniprot.org/uniprotkb/P49767/entry
- NCBI Gene 7424: https://www.ncbi.nlm.nih.gov/gene/7424
- Ensembl ENSG00000150630: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000150630

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Hepatocellular carcinoma](https://onco.cc/cancers/hcc/)

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JSON: https://onco.cc/api/v1/entities/vegfc.json