# VERIFY

Source: https://onco.cc/trials/verify/  
OnCo record `verify` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

VERIFY showed that weekly rusfertide, a hepcidin mimetic, freed most PV patients from phlebotomy and improved their symptoms, leading to the drug's approval in 2026.

## Summary

VERIFY randomised 293 patients with PV who needed frequent phlebotomies to weekly subcutaneous rusfertide or placebo on top of their usual treatment. Over weeks 20 to 32, 77 percent on rusfertide were responders (no phlebotomy needed) versus 33 percent on placebo, with fewer phlebotomies, sustained haematocrit control and better patient-reported fatigue and itch; the results were presented at ASCO 2025 and published the same year. The FDA approved rusfertide in 2026.

## Fields

- Kind: Trial
- Status: positive
- Last checked: 2026-09-16
- Tags: polycythaemia-vera; mpn
- Registry id: NCT05210790
- Phase: 3
- Setting: Phlebotomy-dependent polycythaemia vera: rusfertide versus placebo added to standard care
- Sponsor: Protagonist Therapeutics and Takeda
- Enrolled: 293
- Result: Response (no phlebotomy eligibility) weeks 20 to 32: 77% vs 33%.
- Outcomes: Clinical response weeks 20 to 32: Rusfertide 77% vs Placebo 33%

## Sources

- ClinicalTrials.gov NCT05210790: https://clinicaltrials.gov/study/NCT05210790

## Connected records

- cancers: [Myeloproliferative neoplasms (PV, ET, myelofibrosis)](https://onco.cc/cancers/myeloproliferative-neoplasms/), [Polycythaemia vera (PV)](https://onco.cc/cancers/polycythaemia-vera/)
- drugs: [Rusfertide](https://onco.cc/drugs/rusfertide/)
- companies: [Protagonist Therapeutics](https://onco.cc/companies/protagonist-therapeutics/), [Takeda](https://onco.cc/companies/takeda/)
- terms: [Hepcidin](https://onco.cc/terms/hepcidin/), [Phlebotomy (venesection)](https://onco.cc/terms/phlebotomy/)
- ideas: [Hepcidin-based control as first-line treatment in low-risk polycythaemia vera](https://onco.cc/ideas/idea-pv-hepcidin-first/)

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