# Vindesine

Source: https://onco.cc/drugs/vindesine/  
OnCo record `vindesine` (Treatment). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Vindesine is a vinca alkaloid, a semi-synthetic relative of vinblastine, used in Europe and elsewhere for acute lymphoblastic leukaemia and some solid tumours; it was never marketed in the United States.

## Summary

Vindesine is made from vinblastine and shares the class mechanism of the vinca alkaloids, binding tubulin so microtubules cannot form. It has been used in acute lymphoblastic leukaemia in children and adults, in non-small cell lung cancer combinations in the 1980s and 1990s, and in melanoma and breast cancer, mostly in European protocols. Peripheral neuropathy is its dose-limiting toxicity. It remains a licensed medicine in several European countries but has largely given way to vincristine and vinorelbine.

## Fields

- Kind: Treatment
- Status: established
- Last checked: 2026-09-08
- Also known as: Desacetylvinblastine amide; DVA
- Tags: gap-fill; chembl-universe
- Brand: Eldisine
- Modality: Vinca alkaloid, intravenous
- Mechanism: Binds tubulin and blocks microtubule assembly, arresting dividing cells in metaphase.

## Sources

- Wikipedia: https://en.wikipedia.org/wiki/Vindesine
- Wikipedia: https://en.wikipedia.org/wiki/Vindesine
- ChEMBL CHEMBL1200937: https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200937

## Connected records

- cancers: [Acute lymphoblastic leukaemia](https://onco.cc/cancers/all-leukemia/), [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/)
- targets: [Tubulin (microtubules)](https://onco.cc/targets/tubulin/)
- drugs: [Vinblastine](https://onco.cc/drugs/vinblastine/), [Vincristine](https://onco.cc/drugs/vincristine/), [Vinorelbine](https://onco.cc/drugs/vinorelbine/)

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JSON: https://onco.cc/api/v1/entities/vindesine.json