# VPS37A

Source: https://onco.cc/targets/vps37a/  
OnCo record `vps37a` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

VPS37A (Vacuolar protein sorting-associated protein 37A) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.

## Summary

Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Cetuximab.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: VPS37A subunit of ESCRT-I; Vacuolar protein sorting-associated protein 37A; FLJ32642; HCRP1; SPG53; PQBP2
- Tags: cancer-genes-wave
- Symbol: VPS37A
- Class: other
- Biology: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. Location: Late endosome membrane; Nucleus (UniProt). Locus 8p22 (HGNC).
- Where found: Ovarian cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:24928: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:24928
- UniProt Q8NEZ2: https://www.uniprot.org/uniprotkb/Q8NEZ2/entry
- NCBI Gene 137492: https://www.ncbi.nlm.nih.gov/gene/137492
- Ensembl ENSG00000155975: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000155975

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Ovarian cancer](https://onco.cc/cancers/ovarian/)

---
JSON: https://onco.cc/api/v1/entities/vps37a.json