# VPS53

Source: https://onco.cc/targets/vps53/  
OnCo record `vps53` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

VPS53 (Vacuolar protein sorting-associated protein 53 homolog) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.

## Summary

Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as a component of the EARP complex that is involved in endocytic recycling.

Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.88, genetic association 0.69).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: VPS53 subunit of GARP complex; Vacuolar protein sorting-associated protein 53 homolog; FLJ10979; HCCS1
- Tags: cancer-genes-wave
- Symbol: VPS53
- Class: other
- Biology: Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalised transferrin receptor (TFRC) to the plasma membrane. Location: Golgi apparatus, trans-Golgi network membrane; Endosome membrane; Recycling endosome (UniProt). Locus 17p13.3 (HGNC).
- Where found: Prostate cancer: Open Targets association 0.53 with prostate cancer (MONDO_0008315)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:25608: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25608
- UniProt Q5VIR6: https://www.uniprot.org/uniprotkb/Q5VIR6/entry
- NCBI Gene 55275: https://www.ncbi.nlm.nih.gov/gene/55275
- Ensembl ENSG00000141252: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000141252

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Prostate cancer](https://onco.cc/cancers/prostate/)

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JSON: https://onco.cc/api/v1/entities/vps53.json