# VWF

Source: https://onco.cc/targets/vwf/  
OnCo record `vwf` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

VWF (von Willebrand factor) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Important in the maintenance of haemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilising its heterodimeric structure and protecting it from premature clearance from plasma.

Open Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.97, animal model 0.53, genetic association 0.31).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: von Willebrand factor; F8VWF
- Tags: cancer-genes-wave
- Symbol: VWF
- Class: other
- Biology: Important in the maintenance of haemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilising its heterodimeric structure and protecting it from premature clearance from plasma. Location: Secreted; Secreted, extracellular space, extracellular matrix (UniProt). Locus 12p13.31 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:12726: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12726
- UniProt P04275: https://www.uniprot.org/uniprotkb/P04275/entry
- NCBI Gene 7450: https://www.ncbi.nlm.nih.gov/gene/7450
- Ensembl ENSG00000110799: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000110799

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/vwf.json