# WDR12

Source: https://onco.cc/targets/wdr12/  
OnCo record `wdr12` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

WDR12 (Ribosome biogenesis protein WDR12) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Glioma & glioblastoma.

## Summary

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: WD repeat domain 12; Ribosome biogenesis protein WDR12; YTM1; FLJ10881
- Tags: cancer-genes-wave
- Symbol: WDR12
- Class: other
- Biology: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. Location: Nucleus, nucleolus; Nucleus, nucleoplasm (UniProt). Locus 2q33.2 (HGNC).
- Where found: Glioma & glioblastoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:14098: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14098
- UniProt Q9GZL7: https://www.uniprot.org/uniprotkb/Q9GZL7/entry
- NCBI Gene 55759: https://www.ncbi.nlm.nih.gov/gene/55759
- Ensembl ENSG00000138442: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000138442

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Glioma & glioblastoma](https://onco.cc/cancers/glioblastoma/)

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JSON: https://onco.cc/api/v1/entities/wdr12.json