# WIF1

Source: https://onco.cc/targets/wif1/  
OnCo record `wif1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

WIF1 (Wnt inhibitory factor 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer and Oral cavity cancer.

## Summary

Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.

Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.19, somatic mutation 0.97).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: Wnt inhibitory factor 1
- Tags: cancer-genes-wave
- Symbol: WIF1
- Class: other
- Biology: Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation. Location: Secreted (UniProt). Locus 12q14.3 (HGNC).
- Where found: Breast cancer: Open Targets association 0.55 with breast cancer (MONDO_0007254); Oral cavity cancer: Open Targets association 0.51 with oral cavity cancer (MONDO_0005515)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:18081: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18081
- UniProt Q9Y5W5: https://www.uniprot.org/uniprotkb/Q9Y5W5/entry
- NCBI Gene 11197: https://www.ncbi.nlm.nih.gov/gene/11197
- Ensembl ENSG00000156076: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000156076

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Oral cavity cancer (mouth and tongue)](https://onco.cc/cancers/oral-cavity-cancer/)

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JSON: https://onco.cc/api/v1/entities/wif1.json