# WNT1

Source: https://onco.cc/targets/wnt1/  
OnCo record `wnt1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

WNT1 (Proto-oncogene Wnt-1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Uterine carcinosarcoma.

## Summary

Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signalling pathway by promoting beta-catenin-dependent transcriptional activation. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signalling.

IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Uterine Carcinosarcoma/Uterine Malignant Mixed Mullerian Tumour.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: Wnt family member 1; Proto-oncogene Wnt-1; INT1
- Tags: cancer-genes-wave
- Symbol: WNT1
- Class: tumor-suppressor
- Biology: Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signalling pathway by promoting beta-catenin-dependent transcriptional activation. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signalling. Plays an essential role in the development of the embryonic brain and central nervous system (CNS). Has a role in osteoblast function, bone development and bone homeostasis. Location: Secreted, extracellular space, extracellular matrix; Secreted (UniProt). Locus 12q13.12 (HGNC).
- Where found: Uterine carcinosarcoma: IntOGen driver in 1 cohort (UCS)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:12774: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12774
- UniProt P04628: https://www.uniprot.org/uniprotkb/P04628/entry
- NCBI Gene 7471: https://www.ncbi.nlm.nih.gov/gene/7471
- Ensembl ENSG00000125084: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000125084

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Uterine carcinosarcoma](https://onco.cc/cancers/uterine-carcinosarcoma/)

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JSON: https://onco.cc/api/v1/entities/wnt1.json