# WNT11

Source: https://onco.cc/targets/wnt11/  
OnCo record `wnt11` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

WNT11 (Wnt family member 11) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.

## Summary

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signalling molecule which affects the development of discrete regions of tissues.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: Wnt family member 11
- Tags: cancer-genes-wave
- Symbol: WNT11
- Class: other
- Biology: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signalling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Location: Secreted, extracellular space, extracellular matrix (UniProt). Locus 11q13.5 (HGNC).
- Where found: Colorectal cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:12776: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12776
- UniProt O96014: https://www.uniprot.org/uniprotkb/O96014/entry
- NCBI Gene 7481: https://www.ncbi.nlm.nih.gov/gene/7481
- Ensembl ENSG00000085741: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000085741

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/)

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JSON: https://onco.cc/api/v1/entities/wnt11.json