# WRAP53

Source: https://onco.cc/targets/wrap53/  
OnCo record `wrap53` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

WRAP53 (Telomerase Cajal body protein 1) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.

## Summary

RNA chaperone that plays a key role in telomere maintenance and RNA localisation to Cajal bodies. Specifically recognises and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes.

Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.96, genetic association 0.24, genetic literature 0.76).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: WD repeat containing antisense to TP53; Telomerase Cajal body protein 1; FLJ10385; TCAB1; WDR79
- Tags: cancer-genes-wave
- Symbol: WRAP53
- Class: other
- Biology: RNA chaperone that plays a key role in telomere maintenance and RNA localisation to Cajal bodies. Specifically recognises and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex. Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity. In addition, also controls telomerase holoenzyme complex localisation to Cajal body. Location: Nucleus, Cajal body; Chromosome, telomere; Chromosome (UniProt). Locus 17p13.1 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword "DNA repair". Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:25522: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25522
- UniProt Q9BUR4: https://www.uniprot.org/uniprotkb/Q9BUR4/entry
- NCBI Gene 55135: https://www.ncbi.nlm.nih.gov/gene/55135
- Ensembl ENSG00000141499: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000141499

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/wrap53.json