# WWOX

Source: https://onco.cc/targets/wwox/  
OnCo record `wwox` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

WWOX (WW domain-containing oxidoreductase) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Oesophageal cancer.

## Summary

Putative oxidoreductase. Acts as a tumour suppressor and plays a role in apoptosis. Required for normal bone development.

Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes genetic literature 0.30, literature 0.98, genetic association 0.76, somatic mutation 0.55, animal model 0.49).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: WW domain containing oxidoreductase; WW domain-containing oxidoreductase; WOX1; SDR41C1
- Tags: cancer-genes-wave
- Symbol: WWOX
- Class: enzyme
- Biology: Putative oxidoreductase. Acts as a tumour suppressor and plays a role in apoptosis. Required for normal bone development. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signalling and TGFB1-mediated cell death. May also play a role in tumour necrosis factor (TNF)-mediated cell death. Location: Cytoplasm; Nucleus; Mitochondrion; Golgi apparatus (UniProt). Locus 16q23.1-q23.2 (HGNC).
- Where found: Oesophageal cancer: Open Targets association 0.62 with oesophageal cancer (MONDO_0007576)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:12799: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12799
- UniProt Q9NZC7: https://www.uniprot.org/uniprotkb/Q9NZC7/entry
- NCBI Gene 51741: https://www.ncbi.nlm.nih.gov/gene/51741
- Ensembl ENSG00000186153: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000186153

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Oesophageal cancer](https://onco.cc/cancers/esophageal/)

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JSON: https://onco.cc/api/v1/entities/wwox.json