# XRCC2

Source: https://onco.cc/targets/xrcc2/  
OnCo record `xrcc2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

XRCC2 (DNA repair protein XRCC2) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.

## Summary

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment.

Open Targets scores its association with cancer at 0.70 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.87, genetic association 0.74, genetic literature 0.61).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: X-ray repair cross complementing 2; DNA repair protein XRCC2; FANCU
- Tags: cancer-genes-wave
- Symbol: XRCC2
- Class: other
- Biology: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Location: Nucleus; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (UniProt). Locus 7q36.1 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword "DNA repair". Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:12829: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12829
- UniProt O43543: https://www.uniprot.org/uniprotkb/O43543/entry
- NCBI Gene 7516: https://www.ncbi.nlm.nih.gov/gene/7516
- Ensembl ENSG00000196584: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000196584

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

---
JSON: https://onco.cc/api/v1/entities/xrcc2.json