# YES1

Source: https://onco.cc/targets/yes1/  
OnCo record `yes1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

YES1 (Tyrosine-protein kinase Yes) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Breast cancer, Lung cancer, Leukaemia and 5 more.

## Summary

Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly.

CIViC holds 3 clinical evidence items and 0 assertions across 2 variants, naming Neratinib, Dasatinib and CH6953755. Open Targets scores its association with cancer at 0.76 (direct and indirect evidence; datatypes literature 0.95, affected pathway 0.91, genetic association 0.37, clinical 0.96).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: YES proto-oncogene 1, Src family tyrosine kinase; Tyrosine-protein kinase Yes; Yes; c-yes; HsT441
- Tags: cancer-genes-wave
- Symbol: YES1
- Class: kinase
- Biology: Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signalling pathway and mediates AKT-mediated cell migration. Location: Cell membrane; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm, cytosol; Cell junction (UniProt). Locus 18p11.32 (HGNC).
- Where found: Breast cancer: CIViC evidence names this disease; Lung cancer: CIViC evidence names this disease; Leukaemia: Open Targets association 0.59 with leukaemia (MONDO_0005059); Myeloproliferative neoplasms: Open Targets association 0.58 with myeloproliferative neoplasm (MONDO_0020076); Non-Hodgkin lymphoma: Open Targets association 0.55 with non-Hodgkin lymphoma (MONDO_0018908); Small-cell lung cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.97; CIViC holds 3 clinical evidence items on its variants. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:12841: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12841
- UniProt P07947: https://www.uniprot.org/uniprotkb/P07947/entry
- NCBI Gene 7525: https://www.ncbi.nlm.nih.gov/gene/7525
- Ensembl ENSG00000176105: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000176105

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Acute lymphoblastic leukaemia](https://onco.cc/cancers/all-leukemia/), [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Chronic myeloid leukaemia (CML)](https://onco.cc/cancers/cml/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Myeloproliferative neoplasms (PV, ET, myelofibrosis)](https://onco.cc/cancers/myeloproliferative-neoplasms/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/), [Small-cell lung cancer](https://onco.cc/cancers/sclc/)

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JSON: https://onco.cc/api/v1/entities/yes1.json