# YWHAB

Source: https://onco.cc/targets/ywhab/  
OnCo record `ywhab` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

YWHAB (14-3-3 protein beta/alpha) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Adapter protein implicated in the regulation of a large spectrum of both general and specialised signalling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.92, affected pathway 0.97, animal model 0.30, genetic association 0.00).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; 14-3-3 protein beta/alpha; YWHAA
- Tags: cancer-genes-wave
- Symbol: YWHAB
- Class: other
- Biology: Adapter protein implicated in the regulation of a large spectrum of both general and specialised signalling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonises its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signalling cascades that mediate activation of MAP kinases via AKAP13. Location: Cytoplasm; Melanosome; Vacuole membrane (UniProt). Locus 20q13.12 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:12849: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12849
- UniProt P31946: https://www.uniprot.org/uniprotkb/P31946/entry
- NCBI Gene 7529: https://www.ncbi.nlm.nih.gov/gene/7529
- Ensembl ENSG00000166913: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000166913

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/ywhab.json