# YWHAE

Source: https://onco.cc/targets/ywhae/  
OnCo record `ywhae` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

YWHAE (14-3-3 protein epsilon) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Sarcomas.

## Summary

Adapter protein implicated in the regulation of a large spectrum of both general and specialised signalling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.94, genetic association 0.00, somatic mutation 0.98).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; 14-3-3 protein epsilon; FLJ45465
- Tags: cancer-genes-wave
- Symbol: YWHAE
- Class: other
- Biology: Adapter protein implicated in the regulation of a large spectrum of both general and specialised signalling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm. Plays a positive role in the antiviral signalling pathway upstream of TBK1 via interaction with RIGI. Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signalling during viral infection. Location: Nucleus; Cytoplasm; Melanosome (UniProt). Locus 17p13.3 (HGNC).
- Where found: Sarcomas: Open Targets association 0.59 with sarcoma (MONDO_0005089)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:12851: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12851
- UniProt P62258: https://www.uniprot.org/uniprotkb/P62258/entry
- NCBI Gene 7531: https://www.ncbi.nlm.nih.gov/gene/7531
- Ensembl ENSG00000108953: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000108953

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Sarcomas (soft tissue, bone, GIST)](https://onco.cc/cancers/sarcoma/)

---
JSON: https://onco.cc/api/v1/entities/ywhae.json