# ZBTB10

Source: https://onco.cc/targets/zbtb10/  
OnCo record `zbtb10` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ZBTB10 (Zinc finger and BTB domain-containing protein 10) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Basal cell carcinoma.

## Summary

May be involved in transcriptional regulation.

Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.88, animal model 0.52, genetic association 0.67).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: zinc finger and BTB domain containing 10; Zinc finger and BTB domain-containing protein 10; RINZF; FLJ12752
- Tags: cancer-genes-wave
- Symbol: ZBTB10
- Class: transcription
- Biology: May be involved in transcriptional regulation. Location: Nucleus (UniProt). Locus 8q21.13 (HGNC).
- Where found: Basal cell carcinoma: Open Targets association 0.51 with basal cell carcinoma (MONDO_0020804)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:30953: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30953
- UniProt Q96DT7: https://www.uniprot.org/uniprotkb/Q96DT7/entry
- NCBI Gene 65986: https://www.ncbi.nlm.nih.gov/gene/65986
- Ensembl ENSG00000205189: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000205189

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Basal cell carcinoma](https://onco.cc/cancers/basal-cell-carcinoma/)

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JSON: https://onco.cc/api/v1/entities/zbtb10.json