# ZBTB20

Source: https://onco.cc/targets/zbtb20/  
OnCo record `zbtb20` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ZBTB20 (Zinc finger and BTB domain-containing protein 20) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts.

## Summary

May be a transcription factor that may be involved in haematopoiesis, oncogenesis, and immune responses. Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal.

IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Low-Grade Glioma, NOS.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: zinc finger and BTB domain containing 20; Zinc finger and BTB domain-containing protein 20; ODA-8S; DKFZp566F123; ZNF288
- Tags: cancer-genes-wave
- Symbol: ZBTB20
- Class: tumor-suppressor
- Biology: May be a transcription factor that may be involved in haematopoiesis, oncogenesis, and immune responses. Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal. Location: Nucleus (UniProt). Locus 3q13.31 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Low-Grade Glioma, NOS.

## Sources

- HGNC HGNC:13503: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13503
- UniProt Q9HC78: https://www.uniprot.org/uniprotkb/Q9HC78/entry
- NCBI Gene 26137: https://www.ncbi.nlm.nih.gov/gene/26137
- Ensembl ENSG00000181722: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000181722

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)

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JSON: https://onco.cc/api/v1/entities/zbtb20.json