# ZBTB48

Source: https://onco.cc/targets/zbtb48/  
OnCo record `zbtb48` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ZBTB48 (Zinc finger and BTB domain-containing protein 48) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Angiosarcoma.

## Summary

Plays a critical role in transcriptional regulation and chromatin remodeling. Acts as a regulator of telomere length. Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat.

IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Angiosarcoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: zinc finger and BTB domain containing 48; Zinc finger and BTB domain-containing protein 48; ZNF855; HKR3
- Tags: cancer-genes-wave
- Symbol: ZBTB48
- Class: oncogene
- Biology: Plays a critical role in transcriptional regulation and chromatin remodeling. Acts as a regulator of telomere length. Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres. Also acts as a transcription regulator that binds to promoter regions. Regulates expression of a small subset of genes, including MTFP1. Location: Nucleus; Chromosome, telomere (UniProt). Locus 1p36.31 (HGNC).
- Where found: Angiosarcoma: IntOGen driver in 1 cohort (ANGS)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:4930: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4930
- UniProt P10074: https://www.uniprot.org/uniprotkb/P10074/entry
- NCBI Gene 3104: https://www.ncbi.nlm.nih.gov/gene/3104
- Ensembl ENSG00000204859: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000204859

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Angiosarcoma](https://onco.cc/cancers/angiosarcoma/)

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JSON: https://onco.cc/api/v1/entities/zbtb48.json