# ZBTB7B

Source: https://onco.cc/targets/zbtb7b/  
OnCo record `zbtb7b` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ZBTB7B (Zinc finger and BTB domain-containing protein 7B) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Uterine carcinosarcoma.

## Summary

Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment.

IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Uterine Carcinosarcoma/Uterine Malignant Mixed Mullerian Tumour.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: zinc finger and BTB domain containing 7B; Zinc finger and BTB domain-containing protein 7B; ZBTB15; c-Krox; hcKrox; ZNF857B; vGAF; ThPOK; ZFP67
- Tags: cancer-genes-wave
- Symbol: ZBTB7B
- Class: tumor-suppressor
- Biology: Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Cross-antagonism between ZBTB7B and CBF complexes are determinative to CD4 versus CD8 cell fate decision. Suppresses RUNX3 expression and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signalling. induces, as a transcriptional activator, SOCS genes expression which represses RUNX3 expression and promotes the CD4+ lineage fate. Location: Nucleus (UniProt). Locus 1q21.3 (HGNC).
- Where found: Uterine carcinosarcoma: IntOGen driver in 1 cohort (UCS)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:18668: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18668
- UniProt O15156: https://www.uniprot.org/uniprotkb/O15156/entry
- NCBI Gene 51043: https://www.ncbi.nlm.nih.gov/gene/51043
- Ensembl ENSG00000160685: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000160685

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Uterine carcinosarcoma](https://onco.cc/cancers/uterine-carcinosarcoma/)

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JSON: https://onco.cc/api/v1/entities/zbtb7b.json