# ZC3HAV1

Source: https://onco.cc/targets/zc3hav1/  
OnCo record `zc3hav1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ZC3HAV1 (Zinc finger CCCH-type antiviral protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end.

Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.64, affected pathway 0.89, genetic association 0.00).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: zinc finger CCCH-type containing, antiviral 1; Zinc finger CCCH-type antiviral protein 1; FLB6421; FLJ13288; MGC48898; ZC3HDC2; ZC3H2; PARP13; ARTD13
- Tags: cancer-genes-wave
- Symbol: ZC3HAV1
- Class: other
- Biology: Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae, including human immunodeficiency virus type 1, filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Exhibits stronger antiviral activity than isoform 2 against MuLV expression and Semliki forest virus infection. Location: Nucleus; Lysosome; Late endosome; Cytoplasm (UniProt). Locus 7q34 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:23721: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23721
- UniProt Q7Z2W4: https://www.uniprot.org/uniprotkb/Q7Z2W4/entry
- NCBI Gene 56829: https://www.ncbi.nlm.nih.gov/gene/56829
- Ensembl ENSG00000105939: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000105939

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/zc3hav1.json