# ZCCHC8

Source: https://onco.cc/targets/zcchc8/  
OnCo record `zcchc8` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ZCCHC8 (Zinc finger CCHC domain-containing protein 8) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Gastric & gastro-oesophageal junction cancer.

## Summary

Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs. NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing.

IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Stomach Adenocarcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: zinc finger CCHC-type containing 8; Zinc finger CCHC domain-containing protein 8; DKFZp434E2220
- Tags: cancer-genes-wave
- Symbol: ZCCHC8
- Class: oncogene
- Biology: Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs. NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing. It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function. Location: Nucleus, nucleoplasm; Nucleus (UniProt). Locus 12q24.31 (HGNC).
- Where found: Gastric & gastro-oesophageal junction cancer: IntOGen driver in 1 cohort (STAD)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:25265: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25265
- UniProt Q6NZY4: https://www.uniprot.org/uniprotkb/Q6NZY4/entry
- NCBI Gene 55596: https://www.ncbi.nlm.nih.gov/gene/55596
- Ensembl ENSG00000033030: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000033030

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/)

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JSON: https://onco.cc/api/v1/entities/zcchc8.json