# ZCRB1

Source: https://onco.cc/targets/zcrb1/  
OnCo record `zcrb1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ZCRB1 (Zinc finger CCHC-type and RNA-binding motif-containing protein 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Acute myeloid leukaemia.

## Summary

UniProt has no function text for Q8TBF4; HGNC names it "zinc finger CCHC-type and RNA binding motif containing 1".

IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Acute Myeloid Leukaemia.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: zinc finger CCHC-type and RNA binding motif containing 1; Zinc finger CCHC-type and RNA-binding motif-containing protein 1; MADP-1; MADP1; RBM36; ZCCHC19; SNRNP31
- Tags: cancer-genes-wave
- Symbol: ZCRB1
- Class: oncogene
- Biology: UniProt has no function text for Q8TBF4; HGNC names it "zinc finger CCHC-type and RNA binding motif containing 1". Location: Nucleus, nucleoplasm (UniProt). Locus 12q12 (HGNC).
- Where found: Acute myeloid leukaemia: IntOGen driver in 1 cohort (AML)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:29620: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29620
- UniProt Q8TBF4: https://www.uniprot.org/uniprotkb/Q8TBF4/entry
- NCBI Gene 85437: https://www.ncbi.nlm.nih.gov/gene/85437
- Ensembl ENSG00000139168: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000139168

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Acute myeloid leukaemia](https://onco.cc/cancers/aml/)

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JSON: https://onco.cc/api/v1/entities/zcrb1.json