# Zev A. Wainberg

Source: https://onco.cc/people/zev-wainberg/  
OnCo record `zev-wainberg` (Person). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Led NAPOLI 3, the trial that made NALIRIFOX a first-line option for metastatic pancreatic cancer.

## Summary

Zev Wainberg was principal investigator of NAPOLI 3, which showed NALIRIFOX (liposomal irinotecan, oxaliplatin, fluorouracil) improves survival over gemcitabine plus nab-paclitaxel in metastatic pancreatic cancer, and has led FGFR2b (bemarituzumab) and claudin 18.2 trials in gastric cancer. He co-directs GI oncology at UCLA and runs early-phase GI trials.

## Fields

- Kind: Person
- Last checked: 2026-09-10
- Tags: pancreatic; gastric; trialist
- Role: Professor of Medicine and Co-Director, GI Oncology Program, UCLA Jonsson Comprehensive Cancer Center
- Specialisms: Pancreatic cancer; Gastro-oesophageal cancer; Early drug development; Targeted therapy

## Sources

- PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=Wainberg%20ZA%5BAuthor%5D%20pancreatic%20NAPOLI

## Connected records

- cancers: [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/), [Metastatic pancreatic ductal adenocarcinoma](https://onco.cc/cancers/metastatic-pdac/), [Pancreatic ductal adenocarcinoma](https://onco.cc/cancers/pancreatic/)
- targets: [Claudin 18.2](https://onco.cc/targets/cldn18-2/), [FGFR2](https://onco.cc/targets/fgfr2/)
- institutions: [UCLA Jonsson Comprehensive Cancer Center](https://onco.cc/institutions/ucla-jonsson/)
- trials: [FORTITUDE-101](https://onco.cc/trials/fortitude-101/), [NAPOLI 3](https://onco.cc/trials/napoli-3/)
- key papers: [Daraxonrasib or Chemotherapy in Previously Treated Metastatic Pancreatic Cancer](https://onco.cc/key-papers/paper-daraxonrasib-pancreatic-n-engl-j-med-2026/), [NAPOLI-3: NALIRIFOX versus gemcitabine plus nab-paclitaxel as first treatment for metastatic pancreatic cancer](https://onco.cc/key-papers/paper-napoli-3-lancet-2023/)
- roadmaps: [Pancreatic cancer roadmap: from Whipple's operation to gemcitabine, FOLFIRINOX, adjuvant chemotherapy, PARP inhibition, KRAS inhibition, vaccines and the surveillance question](https://onco.cc/roadmaps/pancreatic-roadmap/)

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