# ZFHX4

Source: https://onco.cc/targets/zfhx4/  
OnCo record `zfhx4` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ZFHX4 (Zinc finger homeobox protein 4) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.

## Summary

May play a role in neural and muscle differentiation. May be involved in transcriptional regulation.

Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.92, animal model 0.43, genetic association 0.63).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: zinc finger homeobox 4; Zinc finger homeobox protein 4; ZFH4; FLJ20980
- Tags: cancer-genes-wave
- Symbol: ZFHX4
- Class: transcription
- Biology: May play a role in neural and muscle differentiation. May be involved in transcriptional regulation. Location: Nucleus (UniProt). Locus 8q21.13 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:30939: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30939
- UniProt Q86UP3: https://www.uniprot.org/uniprotkb/Q86UP3/entry
- NCBI Gene 79776: https://www.ncbi.nlm.nih.gov/gene/79776
- Ensembl ENSG00000091656: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000091656

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/zfhx4.json