# ZHX2

Source: https://onco.cc/targets/zhx2/  
OnCo record `zhx2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ZHX2 (Zinc fingers and homeoboxes protein 2) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Papillary renal cell carcinoma.

## Summary

Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA. May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Sorafenib.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: zinc fingers and homeoboxes 2; Zinc fingers and homeoboxes protein 2; KIAA0854
- Tags: cancer-genes-wave
- Symbol: ZHX2
- Class: transcription
- Biology: Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA. May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells. In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex. Location: Nucleus (UniProt). Locus 8q24.13 (HGNC).
- Where found: Papillary renal cell carcinoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:18513: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18513
- UniProt Q9Y6X8: https://www.uniprot.org/uniprotkb/Q9Y6X8/entry
- NCBI Gene 22882: https://www.ncbi.nlm.nih.gov/gene/22882
- Ensembl ENSG00000178764: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000178764

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Papillary renal cell carcinoma](https://onco.cc/cancers/papillary-rcc/)

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JSON: https://onco.cc/api/v1/entities/zhx2.json