# ZMIZ1

Source: https://onco.cc/targets/zmiz1/  
OnCo record `zmiz1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ZMIZ1 (Zinc finger MIZ domain-containing protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer, Prostate cancer and Colorectal cancer.

## Summary

Acts as a transcriptional coactivator. Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation.

Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.91, genetic association 0.73).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: zinc finger MIZ-type containing 1; Zinc finger MIZ domain-containing protein 1; RP11-519K18.1; KIAA1224; FLJ13541; hZIMP10; Zimp10; RAI17
- Tags: cancer-genes-wave
- Symbol: ZMIZ1
- Class: transcription
- Biology: Acts as a transcriptional coactivator. Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation. Also functions as a transcriptional coactivator in the TGF-beta signalling pathway by increasing the activity of the SMAD3/SMAD4 transcriptional complex. Involved in transcriptional activation of a subset of NOTCH1 target genes including MYC. Involved in thymocyte and T cell development. Location: Nucleus, nucleoplasm; Cytoplasm; Nucleus (UniProt). Locus 10q22.3 (HGNC).
- Where found: Breast cancer: Open Targets association 0.56 with breast cancer (MONDO_0007254); Prostate cancer: Open Targets association 0.55 with prostate cancer (MONDO_0008315); Colorectal cancer: Open Targets association 0.55 with colorectal cancer (MONDO_0005575)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:16493: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16493
- UniProt Q9ULJ6: https://www.uniprot.org/uniprotkb/Q9ULJ6/entry
- NCBI Gene 57178: https://www.ncbi.nlm.nih.gov/gene/57178
- Ensembl ENSG00000108175: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000108175

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Prostate cancer](https://onco.cc/cancers/prostate/)

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JSON: https://onco.cc/api/v1/entities/zmiz1.json