# ZMYM2

Source: https://onco.cc/targets/zmym2/  
OnCo record `zmym2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ZMYM2 (Zinc finger MYM-type protein 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Leukaemia, Prostate cancer, Non-Hodgkin lymphoma and 1 more.

## Summary

Involved in the negative regulation of transcription.

Open Targets scores its association with cancer at 0.70 (direct and indirect evidence; datatypes affected pathway 0.97, literature 0.65, genetic association 0.28, somatic mutation 0.43, animal model 0.41). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Prostate Adenocarcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: zinc finger MYM-type containing 2; Zinc finger MYM-type protein 2; ZNF198
- Tags: cancer-genes-wave
- Symbol: ZMYM2
- Class: oncogene
- Biology: Involved in the negative regulation of transcription. Location: Nucleus (UniProt). Locus 13q12.11 (HGNC).
- Where found: Leukaemia: Open Targets association 0.61 with leukaemia (MONDO_0005059); Prostate cancer: IntOGen driver in 1 cohort (PRAD); Non-Hodgkin lymphoma: Open Targets association 0.53 with non-Hodgkin lymphoma (MONDO_0018908); Acute lymphoblastic leukaemia: Open Targets association 0.53 with acute lymphoblastic leukaemia (MONDO_0004967)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:12989: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12989
- UniProt Q9UBW7: https://www.uniprot.org/uniprotkb/Q9UBW7/entry
- NCBI Gene 7750: https://www.ncbi.nlm.nih.gov/gene/7750
- Ensembl ENSG00000121741: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000121741

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Acute lymphoblastic leukaemia](https://onco.cc/cancers/all-leukemia/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/), [Prostate cancer](https://onco.cc/cancers/prostate/)

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JSON: https://onco.cc/api/v1/entities/zmym2.json