# ZNF217

Source: https://onco.cc/targets/znf217/  
OnCo record `znf217` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ZNF217 (Zinc finger protein 217) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Ovarian cancer and Osteosarcoma.

## Summary

Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonises cell death. Promotes phosphorylation of AKT1 at 'Ser-473'.

CIViC holds 4 clinical evidence items and 0 assertions across 2 variants, naming Triciribine. Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.66).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: zinc finger protein 217; Zinc finger protein 217; ZABC1
- Tags: cancer-genes-wave
- Symbol: ZNF217
- Class: transcription
- Biology: Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonises cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. Location: Nucleus (UniProt). Locus 20q13.2 (HGNC).
- Where found: Breast cancer: CIViC evidence names this disease; Ovarian cancer: CIViC evidence names this disease; Osteosarcoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 4 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:13009: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13009
- UniProt O75362: https://www.uniprot.org/uniprotkb/O75362/entry
- NCBI Gene 7764: https://www.ncbi.nlm.nih.gov/gene/7764
- Ensembl ENSG00000171940: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000171940

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Osteosarcoma](https://onco.cc/cancers/osteosarcoma/), [Ovarian cancer](https://onco.cc/cancers/ovarian/)

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JSON: https://onco.cc/api/v1/entities/znf217.json