# ZNF274

Source: https://onco.cc/targets/znf274/  
OnCo record `znf274` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ZNF274 (Neurotrophin receptor-interacting factor homolog) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Medulloblastoma.

## Summary

Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions.

IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Medulloblastoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: zinc finger protein 274; Neurotrophin receptor-interacting factor homolog; ZKSCAN19; ZSCAN51
- Tags: cancer-genes-wave
- Symbol: ZNF274
- Class: oncogene
- Biology: Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions. Location: Cytoplasm; Nucleus, nucleolus (UniProt). Locus 19q13.43 (HGNC).
- Where found: Medulloblastoma: IntOGen driver in 1 cohort (MBL)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:13068: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13068
- UniProt Q96GC6: https://www.uniprot.org/uniprotkb/Q96GC6/entry
- NCBI Gene 10782: https://www.ncbi.nlm.nih.gov/gene/10782
- Ensembl ENSG00000171606: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000171606

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Medulloblastoma](https://onco.cc/cancers/medulloblastoma/)

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JSON: https://onco.cc/api/v1/entities/znf274.json