# ZNF331

Source: https://onco.cc/targets/znf331/  
OnCo record `znf331` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ZNF331 (Zinc finger protein 331) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Nasopharyngeal carcinoma, Skin cancer and Melanoma.

## Summary

May be involved in transcriptional regulation. May play a role in spermatogenesis.

Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.85, genetic association 0.14, somatic mutation 0.97). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Nasopharyngeal Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: zinc finger protein 331; Zinc finger protein 331; ZNF463; ZNF361
- Tags: cancer-genes-wave
- Symbol: ZNF331
- Class: oncogene
- Biology: May be involved in transcriptional regulation. May play a role in spermatogenesis. Location: Nucleus (UniProt). Locus 19q13.42 (HGNC).
- Where found: Nasopharyngeal carcinoma: IntOGen driver in 1 cohort (NPC); Skin cancer: Open Targets association 0.51 with skin cancer (MONDO_0002898); Melanoma: Open Targets association 0.51 with melanoma (MONDO_0005105)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:15489: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15489
- UniProt Q9NQX6: https://www.uniprot.org/uniprotkb/Q9NQX6/entry
- NCBI Gene 55422: https://www.ncbi.nlm.nih.gov/gene/55422
- Ensembl ENSG00000130844: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000130844

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Melanoma](https://onco.cc/cancers/melanoma/), [Nasopharyngeal carcinoma](https://onco.cc/cancers/nasopharyngeal/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/znf331.json