# ZNF395

Source: https://onco.cc/targets/znf395/  
OnCo record `znf395` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ZNF395 (Zinc finger protein 395) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-small-cell lung cancer.

## Summary

Plays a role in papillomavirus genes transcription.

IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Non-Small Cell Lung Cancer.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: zinc finger protein 395; Zinc finger protein 395; PRF-1; HDBP2; DKFZp434K1210
- Tags: cancer-genes-wave
- Symbol: ZNF395
- Class: oncogene
- Biology: Plays a role in papillomavirus genes transcription. Location: Cytoplasm; Nucleus (UniProt). Locus 8p21.1 (HGNC).
- Where found: Non-small-cell lung cancer: IntOGen driver in 1 cohort (NSCLC)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:18737: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18737
- UniProt Q9H8N7: https://www.uniprot.org/uniprotkb/Q9H8N7/entry
- NCBI Gene 55893: https://www.ncbi.nlm.nih.gov/gene/55893
- Ensembl ENSG00000186918: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000186918

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)

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JSON: https://onco.cc/api/v1/entities/znf395.json