# ZNF429

Source: https://onco.cc/targets/znf429/  
OnCo record `znf429` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ZNF429 (Zinc finger protein 429) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Hepatocellular carcinoma, Prostate cancer and 1 more.

## Summary

May be involved in transcriptional regulation.

Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.17, genetic association 0.00, somatic mutation 0.66). IntOGen calls it a driver in 4 cohorts (1 activating, 2 loss-of-function), covering Bladder Urothelial Carcinoma, Cholangiocarcinoma, Hepatocellular Carcinoma, Prostate Adenocarcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: zinc finger protein 429; Zinc finger protein 429
- Tags: cancer-genes-wave
- Symbol: ZNF429
- Class: transcription
- Biology: May be involved in transcriptional regulation. Location: Nucleus (UniProt). Locus 19p12 (HGNC).
- Where found: Bladder & urothelial cancer: IntOGen driver in 1 cohort (BLCA); Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC); Prostate cancer: IntOGen driver in 1 cohort (PRAD); Biliary tract cancer: IntOGen driver in 1 cohort (CHOL)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:20817: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20817
- UniProt Q86V71: https://www.uniprot.org/uniprotkb/Q86V71/entry
- NCBI Gene 353088: https://www.ncbi.nlm.nih.gov/gene/353088
- Ensembl ENSG00000197013: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000197013

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Biliary tract cancer (cholangiocarcinoma)](https://onco.cc/cancers/cholangiocarcinoma/), [Bladder & urothelial cancer](https://onco.cc/cancers/urothelial/), [Hepatocellular carcinoma](https://onco.cc/cancers/hcc/), [Prostate cancer](https://onco.cc/cancers/prostate/)

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JSON: https://onco.cc/api/v1/entities/znf429.json