# ZNF462

Source: https://onco.cc/targets/znf462/  
OnCo record `znf462` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ZNF462 (Zinc finger protein 462) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organisation. Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG. By binding PBX1, prevents the heterodimerisation of PBX1 and HOXA9 and their binding to DNA.

Open Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.17, animal model 0.34, genetic association 0.77).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: zinc finger protein 462; Zinc finger protein 462; DKFZP762N2316; KIAA1803; Zfp462
- Tags: cancer-genes-wave
- Symbol: ZNF462
- Class: transcription
- Biology: Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organisation. Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG. By binding PBX1, prevents the heterodimerisation of PBX1 and HOXA9 and their binding to DNA. Regulates neuronal development and neural cell differentiation. Location: Nucleus (UniProt). Locus 9q31.2 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:21684: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:21684
- UniProt Q96JM2: https://www.uniprot.org/uniprotkb/Q96JM2/entry
- NCBI Gene 58499: https://www.ncbi.nlm.nih.gov/gene/58499
- Ensembl ENSG00000148143: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000148143

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/znf462.json